Research and Publications

All manuscripts and publications are available on my  or my .

The list below is no longer actively maintained.

 

Preprints

  1. J.M.Wentz and D. M. Bortz. Analytical Singular Value Decomposition for a Class of Stoichiometry Matrices. (submitted)

Refereed Articles & Book Chapters

  1. G. E. Wheeler, A. Purkayastha, E. N. Bunker, D. M. Bortz, and X. Liu. Protocol for measurement and analysis of cell motility of HaCaT keratinocytes on both single-cell and population-wide levels. J. Vis. Exp., (accepted), 2021.
  2. D.A. Messenger and D.M. Bortz. Weak SINDy: Galerkin-Based Data-Driven Model Selection. SIAM Multiscale Mod. & Sim. (accepted). 

  3. J.M. Wentz and D.M. Bortz. Boundedness of a class of discretized reaction-diffusion systems. SIAM J. Appl. Math. (accepted). 

  4. D.A. Messenger and D.M. Bortz. Weak SINDy For Partial Differential Equations. J. Comp. Physics, 443:110525, October 15, 2021.  
  5. A. G. Buchwald, J. Bayham, j. adams, D. M. Bortz, K. Colborn, O. Zarella, M. Buran, J. Samet, D. Ghosh, R. Herlihy, and E. J. Carlton. Estimating the impact of state-wide policies to reduce the spread of SARS-CoV-2 in Colorado in real-time. Emergning Infect. Dis., 27(9), June 2021.
  6. H.J. Dudley, Z.J. Ren, and D.M. Bortz. Competitive Exclusion in a DAE Model for Microbial Electrolysis Cells. Math. Biosci. Eng. 17(5):6217-6239, 2020.
  7. A. G. Buchwald, J. Adams, D. M. Bortz, and E. J. Carlton. Infectious Disease Transmission Models to Predict, Evaluate and Improve Understanding of SARS-COV-2 Trajectory and Interventions. Annals of the American Thoracic Society, 17(10):1204–1206, Oct. 2020.
  8. N. C. Hill, J. W. Tay, S. L. Altus, D. M. Bortz, and J. C. Cameron. Life cycle of a cyanobacterial carboxysome. Science Advances 6(19):eaba1269, 2020.
  9. K. A. Moore, S. L. Altus, J. W. Tay, J. Fox, E. B. Johnson, D. M. Bortz, and J. C. Cameron. Mechanical Regulation of Photosynthesis. Nature Microbiology 5(23 Mar):757-767, 2020.
  10. J. A. Stotsky and D. M. Bortz. A Posteriori Error Analysis of Fluid-Structure Interactions: Time Dependent Error. Computer Methods in Applied Mechanics and Engineering, 356(1 Nov.):1-15, 2019.  
  11. J. T. Nardini and D. M. Bortz. The influence of numerical error on parameter estimation and uncertainty quantification for advective PDE models. Inverse Problems, 35(6):065003, 2019.  
  12. H. J. Dudley, L. Lu, Z. J. Ren, and D. M. Bortz. Sensitivity and Bifurcation Analysis of a Differential-Algebraic Equation Model for a Microbial Electrolysis Cell. SIAM J. Appl. Dyn. Syst., 18(2):709-728, 2019.  
  13. J.A. Stotsky, V. Dukic, & D.M. Bortz. A Point Process Model for Generating Biofilms with Realistic Microstructure and Rheology, Eur. J. Appl. Math., 29(6):1141-1177, Dec. 2018 
  14. E.P. Kightley, A. Pearson, J.A. Evans, & D.M. Bortz. Fragmentation of biofilm-seeded bacterial aggregates in shear flow, Eur. J. Appl. Math., 29(6):1062-1078, Dec. 2018 
  15. J.M. Wentz, A.R. Mendenhall, & D.M. Bortz. Pattern Formation in the Longevity-Related Expression of Heat Shock Protein-16.2 in Caenorhabditis elegans, Bulletin of Mathematical Biology, 80(10):2669-2697, 2018.
  16. J.T. Nardini & D.M. Bortz. Investigation of a Structured Fisher's Equation with Applications in Biochemistry, SIAM J. Appl. Math., 78(3):1712–1736, 2018
  17. V. Dukic & D.M. Bortz, Uncertainty Quantification Using Probabilistic Numerics: Application to Models in Mathematical Epidemiology, Inverse Problems in Science and Engineering, 28(2):223-232, 2018. 
  18. I. Mirzaev and D.M. Bortz. A numerical framework for computing steady states of structured population models and their stability. Math. Biosci. Eng., 14(4):933–952, Aug. 2017.
  19. D.M. Bortz, Characteristic roots for two-lag linear delay differential equations, Discrete and Continuous Dynamical System - B, 21(8): 2409-2422, 2016.
  20. I. Mirzaev, E.C. Byrne, & D.M. Bortz. An Inverse Problem for a Class of Conditional Probability Measure-Dependent Evolution Equations, Inverse Problems, 32(9), 095005, September 2016.  
  21. D.D. Keck & D.M. Bortz. Generalized sensitivity functions for size-structured population models, Journal of Inverse and Ill-posed Problems, 24(3):309-321, June 2016.  
  22. J.T. Nardini, D.A. Chapnick, X. Liu, D.M. Bortz. Modeling Keratinocyte Wound Healing Dynamics: Cell-cell Adhesion Promotes Sustained Collective Migration, Journal of Theoretical Biology, 400(July):103-117, 2016.  
  23. J.A. Stotsky, J.F. Hammond, L. Pavlovsky, E.J. Stewart, J.G. Younger, M.J. Solomon, D.M. Bortz. Variable Viscosity and Density Biofilm Simulations using an Immersed Boundary Method, Part II: Experimental Validation and the Heterogeneous Rheology-IBM, Journal of Computational Physics, 317(July):204-222, 2016 . 
  24. D.M. Bortz. Eigenvalues for a Two-lag linear delay differential equation, IFAC-PapersOnline, 48(12):13-16, 2015 
  25. I. Mirzaev & D.M. Bortz. Laplacian Dynamics with Synthesis and Degradation, Bulletin of Mathematical Biology, 77(6):1013–1045, 2015  .
  26. D.M. Bortz. Chapter 17: Modeling and simulation for nanomaterials in fluids: Nanoparticle self-assembly. In V. Tewary & Y. Zhang, editors, , 419-441, Woodhead/Elsevier, 2015.
  27. S. Sircar, E. Aisenbrey, S. Bryant & D.M. Bortz, Determining average osmolarity in Poly(ethylene glycol)-Chondrotin sulfate gels mimicking cartillage. Journal of Theoretical Biology, 364(Jan):394-406, 2015.  
  28. S. Sircar, J. G. Younger, & D.M. Bortz. Sticky surface: sphere–sphere adhesion dynamics. Journal of Biological Dynamics, 9(sup1): 79-89, 2015  
  29. S.M. Kissler, C. Cichowitz, S. Sankaranarayanan, & D.M. Bortz. Determination of personalized diabetes treatment plans using a two-delay model. Journal of Theoretical Biology, 359(Oct), 101-111, 2014  
  30. J. F. Hammond, E. J. Stewart, M. J. Solomon, J. G. Younger, & D.M. Bortz. Variable viscosity and density biofilm simulations using an Immersed Boundary Method, Part I: numerical scheme and convergence results. Computer Modeling in Engineering & Sciences, 98(3), 295-340, 2014   (Invited paper as a part of a special issue on Computational Mechanobiology and Soft Matter Mechanics.)
  31. G. Lambert, A. Bergman, Q. Zhang, D.M. Bortz, & R. Austin. Physics of Biofilms: The Initial Stages of Biofilm Formation and Dynamics. New J. Physics, 16(4):045005, Apr. 2014. 
  32. S. Sircar & D.M. Bortz. Impact of flow on ligand-mediated bacterial flocculation. Mathematical Biosciences, 245(2):314-321, Oct. 2013. 
  33. A. Satorius, J. Szafranski, A. Rivera, D. Pynes, M. Ghanesan, M. J. Solomon, D. Newton, D.M. Bortz, & J. G. Younger, Complement C5a Generation by Staphylococcus epidermidis Biofilms. SHOCK, 39(4):336-342, Apr. 2013. 
  34. E. C. Conrad, Y.-Y. Hsu, D.M. Bortz, & J. G. Younger. Spatiotemporal Dynamics of Complement C5a Production within Bacterial Extracellular Polymeric Substance. Journal of Innate Immunity, 5(2):114-123, Jan. 2013. (cover art!). 
  35. C. W. Curtis & D.M. Bortz, Propagation of fronts in the Fisher-Kolmogorov equation with quadratically varying diffusion. Phys. Rev. E, 86(6):066108, Dec. 2012.  
  36. M. Thornton, C. Irvin, H. M. Chung, D.M. Bortz, M. J. Solomon, & J. G. Younger, Multicellularity and Antibiotic Resistance in Klebsiella pneumoniae Grown under Bloodstream-Mimicking Fluid Dynamic Conditions. Journal of Infectious Diseases, 206(4):588-595, Aug. 2012. 
  37. J. F. Hammond & D.M. Bortz, Analytical solutions to Fisher’s equation with time-variable coefficients. Applied Mathematics and Computation, 218(6):2497-2508, 2011. 
  38. E. C. Byrne, S. Dzul, M. J. Solomon, J. G. Younger, & D.M. Bortz, Postfragmentation density function for bacterial aggregates in laminar flow. Phys. Rev. E, 83(4):41911, 2011. 
  39. S. P. Dzul, M. M. Thornton, D. N. Hohne, E. J. Stewart, A. A. Shah, D.M. Bortz, M. J. Solomon, and J. G. Younger.Contribution of the Klebsiella pneumoniae Capsule to Bacterial Aggregate and Biofilm Microstructures. Applied Environmental Microbiology, 77(5):1777–1782, Mar. 2011. 
  40. C. M. Nypaver, M. M. Thornton, S. M. Yin, D. O. Bracho, P. W. Nelson, A. E. Jones, D.M. Bortz, & J. G. Younger, Dynamics of Human Complement―Mediated Killing of Klebsiella pneumoniae, American journal of respiratory cell and molecular biology, 43(5):585-590, 2010. 
  41. H. Chung, M. M. Cartwright, D.M. Bortz, T. L. Jackson, & J. G. Younger, Dynamical System Analysis of Staphylococcus epidermidis Bloodstream Infection, SHOCK, 30(5):518-526, November 2008.  (cover art!)
  42. D.M. Bortz, T. L. Jackson, K. A. Taylor, A. P. Thompson, & J. G. Younger, Klebsiella pneumoniae flocculation dynamics, Bulletin of Mathematical Biology, 70(3):745-768, April 2008. 
  43. D.M. Bortz & P. W. Nelson, Model selection and mixed-effects modeling of HIV infection dynamics, Bulletin of Mathematical Biology, 68(8):2005-2025, November 2006. 
  44. S. Ciupe, B. L. Bivort, D.M. Bortz, & P. W. Nelson, Estimating kinetic parameters from HIV primary infection data through the eyes of three different mathematical models, Mathematical Biosciences, 200(1):1-27, March 2006.
  45. I. Ben-David, S. E. Price, D.M. Bortz, S. Cohen, A. L. Bauer, T. L. Jackson, & J. G. Younger, Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspirations, Am. J. Respiratory Cell & Molecular Biology, 33(5):476-482, November 2005. 
  46. H. T. Banks & D.M. Bortz, A parameter sensitivity methodology in the context of HIV delay equation models, Journal of Mathematical Biology, 50(6):607-625, June 2005. 
  47. H. T. Banks & D.M. Bortz, Inverse Problems for a Class of Measure Dependent Dynamical Systems, Journal of Inverse and Ill-posed Problems, 13(2):103-121, April 2005. 
  48. D.M. Bortz & P. W. Nelson, Sensitivity analysis of nonlinear lumped parameter models of HIV infection dynamics, Bulletin of Mathematical Biology, 66(5):1009-1026, September 2004. 
  49. H. T. Banks, D.M. Bortz, G. A. Pinter, & L. K. Potter, Chapter 6: Modeling and imaging techniques with potential for applications in bioterrorism. In H. T. Banks and C. Castillo-Chavez, editors, , volume 28 of Frontiers in Applied Mathematics, pages 129-154, SIAM, Phildelphia, PA, 2003.
  50. H. T. Banks, D.M. Bortz, & S. E. Holte, Incorporation of variability into the mathematical modeling of viral delays in HIV infection dynamics, Mathematical Biosciences, 183(1):63-91, May 2003. 
  51. D.M. Bortz, A. D. Rubio, H. T. Banks, A. B. Cain, & R. C. Smith, Control of open bay acoustics by harmonic mass injection, International Journal of Aeroacoustics, 1(1):65-81, March 2002. 
  52. A. B. Cain, A. D. Rubio, D.M. Bortz, H. T. Banks, & R. C. Smith, Reduced Order Modeling in Control of Open Cavity Acoustics, Proceedings of the AIAA, AIAA-2000-1928, June 2000.
  53. D.M. Bortz & C. T. Kelley, The simplex gradient and noisy optimization problems. In J. T. Borggaard, J. Burns, E. Cliff, and S. Schreck, editors, , volume 24 of Progress in Systems and Control Theory, Birkhauser, 1998, pp. 77-90.
  54. I. Ambats, D.M. Bortz, A. Connolly, A. Derlicki, M. Derrick, W. Kahle, & J. Thron, Studies of Hadron-Electron Separators for the ZEUS Barrel Calorimeter, Nuclear Instruments and Methods in Physics Research Section A, 368(2):364-377, 1996. 

Other Publications

  1. T. Kusher, D.M. Bortz, D. Maahs, S. Sankaranarayanan, A data-driven approach to artificial pancreas verification and synthesis, ICCPS '18 Proceedings of the 9th ACM/IEEE International Conference on Cyber-Physical Systems Pages 242-252, 2018.
  2. S. H. Friedman, A. R. A. Anderson, D. M. Bortz, A. G. Fletcher, H. B. Frieboes, A. Ghaffarizadeh, D. R. Grimes, A. Hawkins-Daarud, S. Hoehme, E. F. Juarez, C. Kesselman, R. Merks, S. M. Mumenthaler, P. K. Newton, K.-A. Norton, R. Rawat, R. C. Rockne, D. Ruderman, J. Scott, S. S. Sindi, J. L. Sparks, K. Swanson, D. B. Agus, and P. Macklin. MultiCellDS: A community-developed standard for curating microenvironment-dependent multicellular data. , Nov. 2016.
  3. S. H. Friedman, A. R. A. Anderson, D. M. Bortz, A. G. Fletcher, H. B. Frieboes, A. Ghaffarizadeh, D. R. Grimes, A. Hawkins-Daarud, S. Hoehme, E. F. Juarez, C. Kesselman, R. M. H. Merks, S. M. Mumenthaler, P. K. Newton, K.-A. Norton, R. Rawat, R. C. Rockne, D. Ruderman, J. Scott, S. S. Sindi, J. L. Sparks, K. Swanson, D. B. Agus, and P. Macklin. MultiCellDS: A standard and a community for sharing multicellular data. , Sept. 2016.
  4. I. Mirzaev & D.M. Bortz. Criteria for linearized stability for a size-structured population model. 
  5. E. C. Conrad, A. E. Satorius, P. Sharma, D.M. Bortz, & J. G. Younger. The Host Response to Line Sepsis: Experimental and Computational Analysis of Complement Activation against Coagulase-Negative Staphylococcal Biofilms. Annals of Emergency Medicine, 62(4):S153, 2013.
  6. J. G. Younger, M. M. Thornton, C. Babcock, H. M. Chung-Esaki, D.M. Bortz, & M. J. Solomon. Bloodstream-like fluid dynamic conditions promote multicellularity and antibiotic resistance in in Klebsiella pneumoniae. SHOCK, 37(1):58, 2012.
  7. D.M. Bortz & A. J. Christlieb. Scandalously Parallelizable Mesh Generation. 
  8. M. M. Thornton, D. N. Hohne, M. J. Solomon, D.M. Bortz, & J. G. Younger. Bacterial aggregation during growth under low shear: implications for bacteremia. SHOCK, 31(7):22, 2009.
  9. D.M. Bortz & A. J. Christlieb. Random numerical discretizations. In Abstracts of the International Conference Inverse Problems: Modeling and Simulation, pages 29–30, 2008.
  10. D. Li, D. Hohne, D.M. Bortz, J. Bull, & J. G. Younger Modeling bacterial clearance from the bloodstream using computational fluid dynamics and monte carlo simulation. J. Critical Care, 22(4):344, Dec. 2007.
  11. J. G. Younger, H. Y. Chung, M. Cartwright, D.M. Bortz, & T. L. Jackson, Neutropenic S-epidermidis bacteremia modeled as a pharmacodynamic system, SHOCK, 27(Supplement 1):68-69, June 2007.
  12. D.M. Bortz. Accurate model selection computations. J. Critical Care, 21(4):359, Dec. 2006.
  13. H. Chung, T. L. Jackson, D.M. Bortz, M. Cartwright, & J. G. Younger, Multiple-compartment bacterial clearance kinetics during murine bacteremia, Journal of Critical Care, 21(4):359-360, December 2006.
  14. D.M. Bortz, T. L. Jackson, & J. G. Younger, Estimation and identification of Klebsiella pneumoniae flocculation dynamics, In Abstracts of the International Conference Inverse Problems: Modeling and Simulation, pages 15-17, 2006.
  15. J. G. Younger, K. Taylor, A. Thompson, & D.M. Bortz. Quantification and modeling of aggregate bacterial growth in suspension: Implications for bacteremia. SHOCK, pages 79–80, June 2006.
  16. I. Ben-David, S. E. Price, S. Cohen, D.M. Bortz, T. L. Jackson, & J. G. Younger, Complement C3 is necessary for early suppression of intrapulmonary bacterial growth, SHOCK, 23(Supplement 3):79-80, June 2005.
  17. A. L. Bauer, D.M. Bortz, D. Gammack, I. Ben-David, A. Stein, T. L. Jackson, & J. G. Younger, Virulence of Klebsiella pneumoniae predicted by nonlinear biodistributive mathematical model, SHOCK, 21(Supplement 2):29,2004.
  18. D.M. Bortz, Modeling, Analysis, and Estimation of an in vitro HIV Infection Using Functional Differential Equations, , North Carolina State University, Raleigh, NC, 2002.
  19. D.M. Bortz, R. Guy, J. Hood, K. Kirkpatrick, V. Nguyen, & V. Shimanovich, Modeling HIV infection dynamics using delay equations, In P. A. Gremaud, Z. Li, R. C. Smith, and H. T. Tran, editors, Proceedings of the 2000 Industrial Mathematics Modeling Workshop for Graduate Students, pages 48-58. Technical Report , Center for Research in Scientific Computation, N. C. State University, Raleigh, NC, October 2000.
  20. A. B. Cain, A. D. Rubio, D.M. Bortz, H. T. Banks, & R. C. Smith, Optimizing control of open bay acoustics, Tech. Report , Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC, May 2000.
  21. A. S. Bondarenko, D.M. Bortz, & J. J. Moré, COPS: Large-scale nonlinearly constrained optimization problems, Tech. Report ANL/MCS-TM-237, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL, September 1998, revised October 1999.
  22. P. Barnes, D.M. Bortz, S. Frank, I. Loladze, E. Packard, & M. Santhanam, Power transformer clearance checking, In F. Reitich, J. S. Scroggs, and H. T. Tran, editors, Proceedings of the 1997 Industrial Mathematics Modeling Workshop for Graduate Students. Technical Report CRSC-TR98-09, Center for Research in Scientific Computation, N. C. State University, Raleigh, NC, February, 1998.